(in Polish) Genome analysis methods 320-ERS-1GANL

Substantive content:
Inherited component of organismal variability - the genome, became the focal point of research, as many of genetic variants can directly affect fitness and health of individuals. Genomes can also elucidate the evolutionary history of many taxonomic groups. The main goal of the course is to introduce students to:
1. Genome architecture in prokaryotes and eukaryotes along with organelles (mitochondria and plastids) and the story behind their acquisition.
2. Standard techniques used in genome sequencing projects (i.e. Human Genome Project) during the emergence of Genomics.
3. Methods used for assessment of genome size and genome mapping (genetic and physical), including cutting-edge optical mapping.
4. Second and third generation of sequencing (sequencing by synthesis, SMRT and nanopore sequencing) and their modifications, used currently for throughput scRNA analyses (10x Chromium).
5. Methods of genome analysis at various levels of organization (TADs, chromatine interactions, open chromatine, transciption factor bindng, epigenetic modifications and gene expression).
6. Comparative genomics and genome evolution.